【A. 抗氧化／氧化壓力：34篇RCT】
1. Hormozi et al., 2019
Effects of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in glazers with occupational cadmium exposure: A randomized, double-blind, placebo-controlled crossover clinical trial
https://doi.org/10.1177/0748233718809256
2. Emami et al., 2018
Effect of Short-term Coenzyme Q10 Supplementation and Precooling on Serum Endogenous Antioxidant Enzymes of Elite Swimmers
https://doi.org/10.1519/JSC.0000000000001971
3. Emami et al., 2018
The effect of short-term coenzyme Q10 supplementation and pre-cooling strategy on cardiac damage markers in elite swimmers
https://doi.org/10.1017/S0007114517003774
4. Singh et al., 2005
Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men
https://doi.org/10.1002/biof.5520250127
5. Kaikkonen et al., 1997
Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: Absorption and antioxidative properties of oil and granule-based preparations
https://doi.org/10.1016/S0891-5849(96)00549-7
6. Zarei et al., 2018
Effects of coenzyme Q supplementation on the serum levels of amylase, adenosine deaminase, catalase, and total antioxidant capacity in women with type 2 diabetes mellitus: A randomized, double-blind placebo-controlled trial
https://doi.org/10.4103/jrms.JRMS_970_17
7. Gholami et al., 2018
Effects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetes
https://doi.org/10.1080/09513590.2018.1481944
8. Sanoobar et al., 2013
Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis
https://doi.org/10.3109/00207454.2013.801844
9. Abdollahzad et al., 2015
Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
https://doi.org/10.1016/j.arcmed.2015.08.006
10. Fallah et al., 2019
Clinical Trial of the Effects of Coenzyme Q10 Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Hemodialysis Patients
https://doi.org/10.4103/ijpvm.IJPVM_418_18
11. Farhangi et al., 2014
Oral coenzyme Q10 supplementation in patients with nonalcoholic fatty liver disease: Effects on serum vaspin, chemerin, pentraxin 3, insulin resistance and oxidative stress
https://doi.org/10.1016/j.arcmed.2014.11.001
12. Ho et al., 2020
Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial
https://doi.org/10.3390/antiox9090823
13. Jahangard et al., 2019
Influence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episode
https://doi.org/10.1007/s11033-019-04989-z
14. Rahmani et al., 2015
Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated with H. pylori infection
https://doi.org/10.1002/jcph.508
15. Raygan et al., 2016
The effects of coenzyme Q10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome
https://doi.org/10.1007/s00394-015-1042-7
16. Gokbel et al., 2016
Effects of Coenzyme Q10 Supplementation on Exercise Performance and Markers of Oxidative Stress in Hemodialysis Patients: A Double-Blind Placebo-Controlled Crossover Trial
https://doi.org/10.1097/MJT.0000000000000166
17. Lee et al., 2012
Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease
https://doi.org/10.1016/j.nut.2011.11.008
18. Lee et al., 2012
Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease
https://doi.org/10.1016/j.nut.2011.06.004
19. Liu et al., 2016
Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: A randomized, placebo-controlled trial
https://doi.org/10.1186/s12937-016-0205-6
20. Ramezani et al., 2020
Coenzyme Q10 supplementation in acute ischemic stroke: Is it beneficial in short-term administration?
https://doi.org/10.1080/1028415X.2018.1541269
21. Shao et al., 2016
Combination Therapy With Coenzyme Q10 and Trimetazidine in Patients With Acute Viral Myocarditis
https://doi.org/10.1097/FJC.0000000000000396
22. Yen et al., 2018
Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: A double-blind, randomised, placebo-controlled trial
https://doi.org/10.1017/S0007114518001241
23. Akbari Fakhrabadi et al., 2014
Effect of Coenzyme Q10 on Oxidative Stress, Glycemic Control and Inflammation in Diabetic Neuropathy: A Double Blind Randomized Clinical Trial
https://doi.org/10.1024/0300-9831/a000211
24. Rodríguez-Carrizalez et al., 2016
The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study
https://doi.org/10.1179/1351000215Y.0000000040
25. Zhang et al., 2018
Treatment of coenzyme Q10 for 24 weeks improves lipid and glycemic profile in dyslipidemic individuals
https://doi.org/10.1016/j.jacl.2017.12.006
26. Gholnari et al., 2018
The Effects of Coenzyme Q10 Supplementation on Glucose Metabolism, Lipid Profiles, Inflammation, and Oxidative Stress in Patients With Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial
https://doi.org/10.1080/07315724.2017.1386140
27. Mohammadshahi et al., 2014
The coenzyme Q10 supplementation effects on lipid profile, fasting blood sugar, blood pressure and oxidative stress status among non-alcoholic fatty liver disease patients: A randomized, placebo-controlled, pilot study
https://doi.org/10.6051/j.issn.2224-3992.2014.03.414
28. Moazen et al., 2015
Effect of coenzyme Q10 on glycaemic control, oxidative stress and adiponectin in type 2 diabetes
未查得 DOI（期刊紀錄未提供 DOI）；文章資料：https://europepmc.org/article/MED/25976576
29. Singh et al., 1998
Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction
https://doi.org/10.1023/A:1007764616025
30. Singh and Niaz, 1999
Serum concentration of lipoprotein(a) decreases on treatment with hydrosoluble coenzyme Q10 in patients with coronary artery disease: Discovery of a new role
https://doi.org/10.1016/S0167-5273(98)00323-4
31. Zhao et al., 2015
Effect of coenzyme Q10 on the incidence of atrial fibrillation in patients with heart failure
https://doi.org/10.1097/JIM.0000000000000202
32. Dai et al., 2011
Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial
https://doi.org/10.1016/j.atherosclerosis.2011.02.013
33. Lee et al., 2013
Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: A randomized, placebo-controlled trial
https://doi.org/10.1186/1475-2891-12-142
34. Tóth et al., 2017
Addition of omega-3 fatty acid and coenzyme Q10 to statin therapy in patients with combined dyslipidemia
https://doi.org/10.1515/jbcpp-2016-0149
【B. 疲勞改善：13篇RCT】
- Berman et al., 2004｜Q10單方
Coenzyme Q10 in Patients with End-Stage Heart Failure Awaiting Cardiac Transplantation: A Randomized, Placebo-Controlled Study
https://doi.org/10.1002/clc.4960270512 - Lee et al., 2011｜Q10單方
Effects of Coenzyme Q10 on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study
https://doi.org/10.1089/jmf.2010.1202 - Cordero et al., 2013｜Q10單方
Can Coenzyme Q10 Improve Clinical and Molecular Parameters in Fibromyalgia?
https://doi.org/10.1089/ars.2013.5260 - Lesser et al., 2013｜Q10單方
A Randomized, Double-Blind, Placebo-Controlled Study of Oral Coenzyme Q10 to Relieve Self-Reported Treatment-Related Fatigue in Newly Diagnosed Patients with Breast Cancer
https://doi.org/10.1016/j.suponc.2012.03.003 - Castro-Marrero et al., 2015｜Q10＋NADH複方
Does Oral Coenzyme Q10 Plus NADH Supplementation Improve Fatigue and Biochemical Parameters in Chronic Fatigue Syndrome?
https://doi.org/10.1089/ars.2014.6181 - Fukuda et al., 2015｜含Q10的綜合營養複方
Effects of Nutritional Supplementation on Fatigue, and Autonomic and Immune Dysfunction in Patients with End-Stage Renal Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
https://doi.org/10.1371/journal.pone.0119578 - Peel et al., 2015｜Q10單方
A Randomized Controlled Trial of Coenzyme Q10 for Fatigue in the Late-Onset Sequelae of Poliomyelitis
https://doi.org/10.1016/j.ctim.2015.09.002 - Sanoobar et al., 2016｜Q10單方
Coenzyme Q10 as a Treatment for Fatigue and Depression in Multiple Sclerosis Patients: A Double Blind Randomized Clinical Trial
https://doi.org/10.1179/1476830515Y.0000000002 - Di Pierro et al., 2017｜Q10單方
Role for a Water-Soluble Form of CoQ10 in Female Subjects Affected by Fibromyalgia. A Preliminary Study
https://scholar.google.com/scholar?q=Role+for+a+Water-Soluble+Form+of+CoQ10+in+Female+Subjects+Affected+by+Fibromyalgia - Morikawa et al., 2019｜Q10單方
Reduced Form of Coenzyme Q10 Relieves Daily Life Stress and Improves Sleep Quality in Healthy Subjects with High Stress Sensitivity — A Randomized, Double-Blind, Parallel-Group Study
https://scholar.google.com/scholar?q=Reduced+Form+of+Coenzyme+Q10+Relieves+Daily+Life+Stress+Improves+Sleep+Quality+Morikawa - Mizuno et al., 2020｜Q10單方
Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals
https://doi.org/10.3390/nu12061640 - Mousavi et al., 2020｜Q10單方
Effect of Coenzyme Q10 Supplementation on Work-Related Fatigue in Nurses: A Double-Blind, Randomized Placebo-Controlled Study
https://doi.org/10.1080/21641846.2019.1704374 - Castro-Marrero et al., 2021｜Q10＋NADH複方
Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
https://doi.org/10.3390/nu13082658
【兩篇統合分析原始來源】
抗氧化統合分析：
Effects of Coenzyme Q10 Supplementation on Biomarkers of Oxidative Stress in Adults: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials
https://www.mdpi.com/2076-3921/11/7/1360
疲勞統合分析：
Effectiveness of Coenzyme Q10 Supplementation for Reducing Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.883251/full
